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SARMs work similarly to testosterone in that they fill the same androgen receptor-binding sites as testosterone does, but they also also bind to more different estrogen receptors, and are able to activate the receptors on estrogen-sensitive cells such as breast and ovarian cells, according to Tuckwell.In women, the difference in binding in the SARS-CoV MRSA and the MERS-CoV is likely due to sex differences in protein structure, Tuckwell said. "It's a good bet we are seeing a difference in the way these molecules are structurally bound to their receptors because of where they bind, because of how a protein can be modified, because of the way receptors are structurally assembled, and also because of where the protein is placed, the size."Although MERS-CoV is more virulent than the SARS variant, it is still a long way from being a new pathogen, according to Tuckwell. The infection has been around longer than SARS, though, and it has not yet emerged as a leading cause of infections. In comparison, MERS-CoV first came into the public eye in 2009 with a case reported in Saudi Arabia, shortly before the outbreak of SARS in 2003. The new strain was brought into the U.S. in early 2012 by a person who traveled from Saudi Arabia, according to the CDC."Given the rapid evolution of MERS-CoV over the past two decades, public health officials are likely to be wary of assuming that we have now got a single strain of the disease, and that will make it harder to understand just how serious it is," Tuckwell said.The new strain has caused a severe respiratory illness known as ebolavirus in some cases, according to the CDC. The latest case occurred in a family traveling during an overseas Haj pilgrimage in the Middle East, where the group had taken an extended break from their hotel room for food and a smoke break. The family member who contracted the infection had a fever, severe cough and wheezing. They were hospitalized with pneumonia, and had to be quarantined.The CDC and WHO have not found any of the other strains in any of the cases. The next round of lab tests to see how the virus is different in other places will take two to three weeks, Tuckwell said. After that, a more thorough analysis of all the isolates will be done.Tuckwell noted that, despite such rapid-fire changes, the current outbreak is likely to be controlled. HeSimilar articles: